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Fundraising to pay for biomedical research towards test, cause and cure for fibromyalgia

DUCK30 £3 to 70070 OR DUCK05 £5 to 70070 OR DUCK10 £10 to 70070 OR DUCK20 to 70070

Research News Update

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An important announcement from the trustees of the Fibroduck Foundation

The Fibroduck Foundation is pleased to announce that we have been offered, and the Trustees have accepted, the opportunity to join a prestigious biomedical study into the mechanisms of pain and fatigue in Fibromyalgia being carried out by Brighton and Sussex Medical School, part of the University of Sussex.

The full title of the study is: ‘Viscero-sensory Processes and Neural Responses to Inflammation: Mechanisms of Pain and Fatigue in Fibromyalgia’. The short name for the project is: ‘Mechanisms of Chronic Pain and Fatigue’.

The primary aim of the study is to identify the main causes of pain and fatigue in fibromyalgia so that evidence-based treatments can be developed.

The project is already under way, and you can read about the existing arms of the study on this link: https://theconversation.com/fibromyalgia-researchers-trying-to-fathom-the-causes-of-this-painful-condition-102946

The funds raised by The Fibroduck Foundation will be invested in this multi-faceted biomedical study to help the team extend their work.

The specific areas of study in which we are investing is twofold:

The costs of up to 12 months of research staff time for analysis and interpretation of data already generated by the autonomic dysfunction arm of the project, and

Specialist consumable support for a new transcriptomic analysis arm of the project.

Explained in plain English

The University research team has produced far more data than it has the resources to analyse. With this donation, they will now be able to process, analyse and disseminate critical physiological data that has already been collected as part of their project. It is hoped that this data will confirm the importance of autonomic dysfunction (including orthostatic intolerance) in the generation of pain and fatigue symptoms in patients with Fibromyalgia.

It is already known in the scientific and medical communities that orthostatic intolerance is common in both Fibromyalgia and ME/CFS. This project hopes to demonstrate this relationship directly, and link it with changes in pain, fatigue and responsivity to inflammation in patients with Fibromyalgia.

It is hoped that this part of the study could deliver scientific knowledge that has the potential to influence targeted treatments.

The specialist consumable resource we are funding will support the analysis of genome-wide transcriptomics. Transcriptomatics takes a bit of explaining, so bear with us. Everyone has heard of DNA but do you know that your DNA subtly changes with the things that happen in your life? The story of what has happened to your body, health-wise, and age-

wise, is written into your DNA. Transcriptomatics is the new scientific field which aims to decode and analyse those changes, in order to understand what has happened to the body when we get ill.

Scientists on other projects have already shown that people who have medical conditions with a lot of fatigue and pain have changes in their transcriptomatics. This study now aims to go further, and show the transcriptomic differences associated with an inflammatory challenge in patients with Fibromyalgia. This too has the potential to influence further scientific research and ultimately treatment targets.

The main research programme is already under way, and the team is led by Professor Kevin Davies, who is Head of the Department of Clinical & Experimental Medicine at the University, and also practices Rheumatology as Honorary Consultant at Brighton and Sussex University Hospitals Trust. He is also the Trust’s Associate Medical Director, Head of Research and Development. His bio is here https://www.bsms.ac.uk/about/contact-us/staff/professor-kevin-davies.aspx

The existing arms of the study are focused on: autonomic dysfunction; hypermobility and the role of collagen; and the abnormal responses of FM patients’ bodies to (what would be to healthy people) minor challenges such as vaccines. By looking at different aspects of the condition, we believe the study overall will have direct relevance to most of our patient community.

As Trustees, we feel this is the best use of the funds raised by patients and their supporters, because, through the various arms of the study, it will have direct implications for diagnosis and treatment of the majority of patients with fibromyalgia. In discussion with Professor Davies, it is clear that he is extremely well in tune with the symptoms experienced by people with fibromyalgia (PWFM) and potential causes.

The team have also undertaken to provide updates on at least a six-monthly basis, with an initial online video to be released on May 12th 2019. A link for the video will be released on our web site www. Fibroduckfoundation.com and on our Facebook groups.